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KMID : 0370220100540030168
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Yakhak Hoeji
2010 Volume.54 No. 3 p.168 ~ p.173
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Anti-proliferative Effects of Daidzein, Baicalein, Hesperidin and Ursolic Acid on Human Breast Cancer Cells Stimulated by Estrogenic Compounds
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Lee Mi-Nam
Lee Su-Yel
Lee Hyun-Jae
Seok Jeong-Ho
Lee Choong-Jae
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Abstract
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We investigated whether three flavonoids including daidzein, baicalein, hesperidin and ursolic acid, a triterpene acid, affect proliferation of MCF-7 human breast cancer cells stimulated by estrogenic compounds. Ursolic acid and baicalein inhibited proliferation of MCF-7 cells induced by PhIP, a food-derived carcinogen with estrogenic activity. Daidzein and hesperidin inhibited estradiol-induced proliferation of MCF-7 cells. These compounds should be further investigated for the possible involvement in signaling pathway after estrogen receptor binding in breast cancer cells.
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KEYWORD
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flavonoids, triterpenoids, MCF-7, cytotoxicity
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